Available painkillers: esters and amides
Bibliography
1 GRLS, r/u LP-004175 dated 03/03/2017
2 Certificate GMP-0036-000221/18
3 Greveling K, Prens EP, Ten Bosch N, van Doorn MB. Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials. Br J Dermatol. 2016 Jul 5. doi:10.1111/bjd.14848 Hernandez E.;
4 J. Cassuto, R. Sinclair, M. Bonderovic, Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 2006; 50; 265-282]
5 Based on IQVIA report March 2022 - September 2022
6 Russian medical journal. Zhigultsova T.I., Parkaeva L.V., Ilyina E.E., Vissarionov V.A.: “Experience of using 5% Emla cream in the practice of dermatocosmetologists”
7 Instructions for use of the medicinal product for medical use Acriol Pro
8 T.N. Calvey, N.E. Williams. Pharmacology for anesthesiologists. Publishing house Binom, Moscow, 2007, 119-128
9 Based on the report “Anesthetics in injection cosmetology for 2016” Vademecum Analytical Center for sales volume.
10 T.I. Zhigultsova, Ph.D. L.V. Parkaeva, E.E. Ilyina, professor V.A. Vissarionov: “Experience of using 5% Emla cream in the practice of dermatocosmetologists” Cosmetology and plastic surgery. Vol. 16, No. 9, 2008
11 On the Russian market there are so-called cosmetic products containing lidocaine and not registered as medicines
12 Cling film can be used as an occlusive dressing
13 Drug Release Studies on an Oil-Water Emulsion Based on a Eutectic Mixture of Lidocaine and Prilocaine as the Dispersed Phase
14 Federal Law-61 “On the Circulation of Medicines” dated April 12, 2010, Federal Law-323 “On the Fundamentals of Protecting the Health of Citizens in the Russian Federation” dated November 21, 2011 and Federal Law-532 “On Amendments to Certain Legislative Acts of the Russian Federation Regarding Counteraction to Trafficking falsified, counterfeit, substandard and unregistered medicines, medical devices and counterfeit dietary supplements" dated December 31, 2014.
15 Federal Law-532, Technical Regulations of the Customs Union on the safety of perfumery and cosmetic products, Federal Law 61, Federal Law 532, Criminal Code of the Russian Federation, Art. 235, 238, 227
16 V.V. Osipova.MMA named after. I.M. Sechenov. Psychological aspects of pain. Lecture. №1/2010
17 According to GMP News. Analysis of the market for local anesthetics used in cosmetic injections in 2022.
18 One type of occlusive dressing, namely: bandage, cling film, adhesive tape or rubberized fabric
19 The combination of lidocaine and prilocaine in concentrations above 0.5-2% has bactericidal and antiviral properties. In Akriol Pro the concentration is 5%.
20 A.A. Stepanov, G.V. Yatsyk, L.S. Namazova Method of preventing pain in young children during vaccination // Into the practice of pediatricians - 09.14.2006 -
21 N.V. Klipinina, RMJ, Some features of the perception and experience of pain by children: a psychologist’s view, reprint. 2007.1-7
22 E.A. Ranneva. The use of EMLA® cream in the complex correction of cosmetic imperfections. Experimental and clinical dermatocosmetology 2010, No. 2: 48-53.
23 Gonzalez S. Evaluation of Topical Anesthetics by Laser-Induced Sensation. Lasers in Surgery and Medicine 23:167–171(1998));
24 V.G. Lebedyuk et al. Anesthesia in dermatocosmetology. Experimental and clinical dermatocosmetology, 2010 No. 5
25 Meltem F. Söyleva Nilüfer Koçaka Bahar Kuvakia Seyhan B. Özkanb Erkin Ki˙rb; Anesthesia with Cream for Botulinum A Toxin Injection into Eyelids. Ophthalmologica 2002;216:355–358
26 E.V. Matuszewska and authors. Topical local anesthetics in cosmetology. Clinical Dermatology and Venereology. 03.2017 pp. 89-96
27 Therapeutics and Clinical Risk Management 2006:2(1) 99 – 113
28 F. Michael Ferrante, Timothy R. Wade Bopcore Postoperative Pain. Management. Per. from English/Ed. M.: Medicine, 1998.- 640 pp., p. 243
29 Lakhin R.E. Local anesthetics. Department of Anesthesiology and Reanimatology of the Military Medical Academy named after. S.M.Kirova, St. Petersburg, 2013, Committee on Ultrasound Technologies of the All-Russian public organization “Federation of Anesthesiologists and Resuscitators.” Clinical guidelines “Intensive therapy for systemic toxicity with local anesthetics. Moscow - St. Petersburg 2015 Page. 10 https://www.far.org.ru/recomendation
30 Wetter DA et al. J American Acad. Dermatol. 2010;63(5):789-98
31 https://www.1nep.ru/articles/issledovanie-sostava-populyarnykh-mestnykh-anestetikov/
32 ORDER OF THE MINISTRY OF HEALTH OF THE RUSSIA dated 08.10.2015 No. 707n
33 Davydov O.S. Peripheral and central mechanisms of the transition of acute pain to chronic pain and the possible role of cyclooxygenase 2 inhibition in the prevention of chronic pain syndrome. Neurology, neuropsychiatry, psychosomatics. 2016;8(2):10-16.
34 J. ALASTAIR CARRUTHERS, MD, JEAN DA CARRUTHERS, MD. Safety of Lidocaine 15% and Prilocaine 5% Topical Ointment Used as Local Anesthesia for Intense Pulsed Light Treatment. Dermatologic Surgery 2010;36:1130–1137
35 Ya-Xian et al. The number of cells in the stratum corneum of normal skin depending on the anatomical location on the body, age, gender and physical parameters Archives Dermatol Res 1999; 291:555–559.
36 J. Morgan, Magid S. Michael. Clinical anesthesiology, Book 1. Binomial. Moscow St. Petersburg, 2001
37 Arendt-Nielsen L, Bjerring P, Nielsen J. Acta Derm Venereol 1990;70:314-318
38 Belarusian State Medical University. 2nd Department of Therapeutic Dentistry. Therapeutic dentistry. Part 1. Ed. A.G. Tretyakovich, L.G. Borisenko.
39 Dermatol Surg 1999;25:950-954
40 K. Greveling et al. Br J Dermatol 176(1), 81-86. 2016 Dec 10
41 Juhlin and Evers Adv Dermatol 1990;5:75-92
42 Arendt-Nielsen L, Bjerring P, Nielsen J. Acta Derm Venereol 1990;70:314-318
43 Study Desensor 001. Wahlgren CF, Quiding H. J Am Acad Dermatol 2000;42:584-8.
44 https://www.1nep.ru/estetic/articles/13952/
45 Guide to dermatocosmetology, edited by E.R. Arabia and E.V. Sokolovsky. St. Petersburg: Foliant Publishing House LLC, 2008 - 632 pp.
46 https://www.1nep.ru/estetic/articles/132197/
47 https://medside.ru/dikain
48 https://medi.ru/instrukciya/novokain_9473/
49 https://medside.ru/anestezin
50 https://grls.rosminzdrav.ru/Default.aspx
51 Radman et al.2002, Yamashita., 2003
52 https://www.krasotaimedicina.ru/diseases/hematologic/methemoglobinemia
53 Evers H, Scott B, Dahlquist AC. Dermal analgesia after epicutaneous application of 5% cream, 5% prilocaine cream, 5% lidocaine cream and placebo cream, to volunteers. Study 89EM03 (n= 21, cross-over). CSR 802-10AC088-2,1989.
54 MASMI. A study of users of skin anesthetics. June 2018
55 O.M. Burylina, A.V. Karpova. Cosmetology. Clinical guidelines. GEOTAR-Media. Moscow, 2018
56 Postoperative pain: the role of peripheral and central sensitization mechanisms. https://rsra.rusanesth.com/publ/posleoperatcionnaya_bol.html
57 Paul M. Friedman, MD, Jushua P. Fogelman, MD and others. Comparative Study of the Efficacy of Four Topical Anesthetics. Dermatolog Surg 1999; 25:950-954
58 https://www.1nep.ru/articles/rynok-kosmeticheskikh-anestetikov-dlya-kozhi/
59 https://www.rlsnet.ru/mnn_index_id_879.htm
60 https://yandex.ru/health/pills/product/ultrakain-ds-2195
61 https://grls.rosminzdrav.ru/Default.aspx on 02/15/2021
62 Ziganshin O.R. Comparison of the effectiveness and safety of topical local anesthetics for superficial surgical interventions in dermatology. Clinical dermatology and venereology. 2018;17(6):53-60. https://doi.org/10.17116/klinderma 20181706153
63 Comparison of Topical Anesthetics for Radiofrequency Ablation of Achrocordons: Eutectic Mixture of Lignocaine/Prilocaine versus Lidocaine/Tetracaine Pratik Gahalaut,1 Nitin Mishra,1 Sandhya Chauhan,2 and Madhur Kant Rastogi11Department of Dermatology, Venereology and Leprosy, Shri Ram Murti Smarak Institute of Medical Sciences, Nainital Road, Bareilly 243001, India2Department of Pediatrics, Shri Ram Murti Smarak Institute of Medical Sciences, Nainital Road, Bareilly 243001, India
64 https://www.gazeta.ru/science/2012/11/01_kz_4837701.shtml
65 https://www.kp.md/daily/23716.3/53610/
66 https://doktorbel.livejournal.com/29873.html
67 https://politeka.net/zdorovye/870023-uchenye-vyjasnili-kak-muzhchiny-i-zhenshhiny-zapominajut-bol-kto-vynoslivee/
68 https://spacefacts.ru/news/people-and-medicine/psychology/792-udovolstvie-ili-bol.html
69 https://tattooinfo.ru/raznoe/foto-prokolotoj-guby-vidy-kak-delat-uxod-za-mestom-prokola.html
70 https://tatuazhpro.ru/pirsing/indastrial.html
71 https://sprs-therapy.ru/faq/V-kakih-sluchayah-nuzhno-primenyat-SPRS-terapiyu_i-v-kakih-nelzya
72 https://sprs-therapy.ru/faq/Kakim-obrazom-provoditsya-SPRS-terapiya
73 https://cosmetology-info.ru/6425/Metody-udaleniya-vtorogo-podborodka/
74 https://beauty.net.ru/public/inektsionnaya_konturnaya_plastika_nososleznoy_borozdy/
75 https://www.1nep.ru/articles/131016/
76 Morrison A.V., Bocharova Yu.M., Morrison V.V. Botulism toxin - a therapeutic effect in cosmetology (review). Saratov Scientific and Medical Journal 2016; 12(3):521–524.
77 A.V. Gara, V.G. Zolotareva, Features of botulinum therapy for aesthetic indications for patients over 45 years old, Injection methods in cosmetology No. 4-2011 – 54-60 s
78 Methodological manual on mesotherapy for students of postgraduate and additional professional education. / Shamov B.A., Dyadkin V.Yu., Zhelonkina T.I./ – Kazan: KSMU, 2011. – 60 p.
79 https://www.1nep.ru/estetic/articles/119953/
80 Evers H, Scott B, Dahlquist AC. Dermal analgesia after epicutaneous application of EMLA 5% cream, 5% prilocaine cream, 5% lidocaine cream and placebo cream, to volunteers. Study 89EM03 (n= 21, cross-over). CSR 802-10AC088-2,1989.
81 https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019941
82 Superficial, medium or deep peeling: what to choose - https://medbooking.com/blog/post/
83 Features of medium peels – https://www.1nep.ru/estetic/articles/190169/
84 Facial peeling – https://cosmetology-info.ru/668/Piling-litsa/
85 Plastic surgery of cheekbones with fillers – https://cheap-fillers.ru/articles/plastika-skul-fillerami
86 Ozone therapy (O3) for the face - a revolutionary beauty technology - https://plastichno.com/cosmetology/ozonoterapiya-dlya-litsa#i-7
87 Effective face lift with liquid mesothreads: what is it and what are the popular brands? – https://beautyexpert.pro/kosmetologiya/inektsionnaya/tredlifting/vidy-nitej/zhidkie-mezoniti.html
88 Mesotherapy of the periorbital area using peptide cocktails – https://www.manuolog.ru/info/about/articles/stati-po-kosmetologii/mezoterapiya-periorbitalnoy-oblasti-s-primeneniem-peptidnykh-kokteyley/
89 Enzyme hair removal: getting rid of excess vegetation – https://plastikaplus.ru/kosmetologiya/epilyaciya/enzimnaya.html
90 Liquid mesothreads and traditional threadlifting: advantages and disadvantages – https://aesthetic-futures.com.ua/zhidkie-mezoniti-i-tradicionnyj-tredlifting-preimushhestva-i-nedostatki
91 Cannula in cosmetology and medicine – https://ladysdream.ru/kanyulya.html
92 7 myths about anesthesia: what are we afraid of? – https://www.psychologies.ru/articles/7-mifov-o-narkoze-chego-myi-boimsya/
93 Medium peeling - an uncompromising method of rejuvenation - https://plastichno.com/cosmetology/sredinnyj-piling#i-3
94 Khunger N. Standard guidelines of care for chemical peels. Indian J Dermatol Venereol Leprol 2008;74(Suppl):S5-S12 – https://pro.bhub.com.ua/cosmetology/himiceskie-pilingi-standartnye-rekomendacii-po-primeneniu#
95 Kim Lawless - 10 secrets of successful hair removal - https://www.cosmo.ru/beauty/body/10-sekretov-udachnoy-epilyacii/
96 All about Sugaring - https://www.gabbi-shugaring.ru/vse-o-shugaringe#rec61612476
97 Hirsutism – https://www.krasotaimedicina.ru/diseases/zabolevanija_endocrinology/hirsutism
98. Intralesional interferon therapy for recurrent warts, G. E. Bagramova, T.G. Sedova, A.N. Khlebnikova // Russian Journal of Skin and Venereal Diseases No. 1, 2013 – 23-26 p.
99. Korolkova T.N., Goma S.E. Study of the effect of mesotherapy with pineal gland peptides on skin moisture and elasticity, Russian Journal of Skin and Venereal Diseases. 2017; 20(5) – 305-310 p.
100. S.V. Klyuchareva, S.M. Nikonova, I.V. Ponomarev, Laser treatment of benign pigmented skin tumors, experimental and clinical dermatocosmetology No. 3, 2006 – 22-31 p.
101. Photorejuvenation in the complex correction of age-related skin changes, N.I. Tsisanova, Journal of Applied Aesthetics No. 1, 2007
102. https://plastichno.com/cosmetology/fotoomolozhenie
103. Current state of the problem of human papillomavirus infection / L. A. Yusupova, E. I. Yunusova, Z. Sh. Garayeva, G. I. Mavlyutova, K. A. Salakhutdinova // Attending physician No. 7/2019; Page numbers in the issue: 64-67 – https://www.lvrach.ru/2019/07/15437345
104. Human papillomavirus infection of the genitals in women, S.I. Rogovskaya, V.N. Prilepskaya, E.A. Mezhevitinova, M.N. Kostava // Bulletin of Dermatology and Venereology, N 6-1998, pp. 48-51. – https://nature.web.ru/db/msg.html?mid=1178539&uri=index.html
105. https://www.1nep.ru/estetic/articles/183501/
106. https://www.1nep.ru/articles/208888/
107. https://cosmetology-info.ru/6925/salon-procedures-Lipolitiki-dlya-litsa/
108. https://www.1nep.ru/articles/204894/
109. https://www.verywellhealth.com/stratum-corneum-anatomy-1069189
110. Turkin P.Yu., Rodionov S.V., Somov N.O., Mirgatia I.O. Venous trophic ulcers: current state of the issue // General Medicine. 2022. No. 1. URL: https://cyberleninka.ru/article/n/venoznye-troficheskie-yazvy-sovremennoe-sostoyanie-voprosa
111. Kruglova Larisa Sergeevna, Panina Anastasia Nikolaevna, Strelkovich Tatyana Igorevna Trophic ulcers of venous origin // Russian Journal of Skin and Venereal Diseases. 2014. No. 1. URL: https://cyberleninka.ru/article/n/troficheskie-yazvy-venoznogo-geneza
112. Yu.M. Stoiko, A.I. Kirienko, I.I. Zatevakhin, A.V. Pokrovsky, A.A. Karpenko et al., Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases // Phlebology No. 3, 2022 – 143-240 pp. — https://webmed.irkutsk.ru/doc/pdf/ven2009.pdf
113. Dovnar R.I., Smotrin S.M. Trophic ulcers of the lower extremities: modern aspects of etiology and pathogenesis // Journal of GrSMU. 2009. No. 4 (28). URL: https://cyberleninka.ru/article/n/troficheskie-yazvy-nizhnih-konechnostey-sovremennye-aspekty-etiologii-i-pathogeneza
114. Burleva E.P., Babushkina Yu.V. Experience in outpatient treatment of trophic foot ulcers that complicated the course of diabetes mellitus // Hospital-replacing technologies: Outpatient surgery. 2022. No. 3-4. URL: https://cyberleninka.ru/article/n/opyt-ambulatornogo-lecheniya-troficheskih-yazv-stop-oslozhnivshih-techenie-saharnogo-diabeta
115. Kutsenko I.V., Andrashko Yu.V. Conservative treatment of trophic ulcers of the lower extremities in chronic venous insufficiency // Methodological recommendations. 2007. https://medinfo.center/wp-content/uploads/2019/12/metodichka-tya.pdf
116. Trophic ulcers of the lower extremities in outpatient clinic practice//Methodological recommendations for fourth-year students of the Faculty of Medicine. 2020 https://rsmu.ru/fileadmin/templates/DOC/Faculties/LF/fsurg2/algoritm_dignost/UP/3._UP_Troficheskie_rasstroi__stva_kozhi_nizhnikh_konechnostei__.pdf
117. Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases. Phlebology, issue No. 2. 2013 https://www.mrckb.ru/files/flebologii.pdf
118. I. L. Mikitin, G. Z. Karapetyan, L. V. Kochetova, S. V. Yakimov, R. A. Pakhomova Modern view on the treatment of trophic ulcers // Creative surgery and oncology. 2013. No. 4. URL: https://cyberleninka.ru/article/n/sovremennyy-vzglyad-na-lechenie-troficheskih-yazv
119. Aralova M.V. Personalized technology for regional treatment of patients with trophic ulcers of the lower extremities. dis. for the academic degree of Doctor of Medical Sciences Voronezh, 2019
120. Lok et al. J Amer Acad Derm 1999;40:208-13. (Study EM9405)
121. Hansson C et al. Acta Derm Venereol (Stockh) 1993;73:231-233.
122. Order of the Ministry of Health of Russia dated October 13, 2017 No. 804n “On approval of the range of medical services.
123. Order of the Ministry of Health dated October 8, 2018 No. 707n “On approval of qualification requirements for medical and pharmaceutical workers with higher education in the field of training “Health and Medical Sciences”
124. 124. Starostina L.S. Helping control pain in children: advice from a pediatrician. Medical advice. 2021;(1):263–268. doi: 10.21518/2079-701X-2021-1-263-268
Indications for use
Local anesthetic preparations are widely used in dentistry for infiltration anesthesia - during tooth extraction (removal) and minor operations on the periodontium (gums).
In order to achieve superficial anesthesia, local anesthetics are used in ophthalmology - in the form of eye drops during operations on the conjunctiva (for laser vision correction, removal of foreign bodies from the eye) and the cornea.
In addition, local anesthetics for superficial anesthesia are used for wounds, minor surgical operations on the skin and mucous membranes, and for ulcers, including gastric ulcers - some local anesthetic preparations (for example, benzocaine) are part of combination drugs that reduce the acidity of gastric juice (antacids).
Certain drugs (lidocaine) are used in endoscopic diagnostics to facilitate the procedure - anesthesia of the pharynx before inserting a tube through the mouth or nose; placement of a urinary catheter.
To achieve conduction anesthesia, local anesthetics are used for pain relief during childbirth (epidural anesthesia), operations on the pelvic organs and lower extremities.
The local anesthetic lidocaine, in addition to its local anesthetic effect, has an antiarrhythmic effect, so it is also used for heart rhythm disturbances - arrhythmias.
Basics of local anesthetic treatment
Preparations for conduction and infiltration anesthesia are produced exclusively in the form of solutions for injection; they are classified as prescription drugs. The administration of these drugs is carried out strictly by medical personnel in a clinical setting and under the mandatory supervision of a doctor.
From the moment of administration of the local anesthetic to the development of local anesthesia, it takes from several minutes to half an hour - it all depends on the specific drug. Therefore, you need to wait for the effect of the drug and not re-introduce it - this is dangerous due to the development of the toxic effect of the local anesthetic.
The duration of the effect of local anesthetics is different and depends on the chemical structure of the drug: esters of para-aminobenzoic acid are quickly destroyed by special esterase enzymes in human tissues, while substituted acetanilide amides are insensitive to the action of these enzymes, and therefore have a much longer local anesthetic effect.
Features of treatment with local anesthetics
For conduction and infiltration anesthesia, only sterile solutions of local anesthetics are used.
The effect of local anesthetics is weak or practically absent during inflammation - increased acidity (acidosis) is observed in inflamed tissues, which prevents the entry of local anesthetic drugs into the nerve cell, which is critical for the development of the drug’s effect.
Certain local anesthetics (articaine, lidocaine) can be combined with vasoconstrictor drugs, in particular with adrenaline (epinephrine). This helps the local anesthetic stay at the injection site longer without entering the systemic circulation. At the same time, the duration of the local anesthetic effect of the drug increases several times. In addition, adrenaline reduces the toxic effect of local anesthetics on the body.
Considering that local anesthetics (especially esters) often cause allergic reactions, before using these drugs it is advisable to determine individual sensitivity to them - inject the patient with a small amount of local anesthetic solution under the skin of the forearm and assess the reaction after five to ten minutes.
